# Science article on negative feedback loop

**URL:** <http://discourse.iapct.org/t/science-article-on-negative-feedback-loop/10253>\
**Category:** CSG2002\
**Created:** [November 14, 2002, 7:47pm UTC](http://discourse.iapct.org/t/science-article-on-negative-feedback-loop/10253 "2002-11-14T19:47:28Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![Bill\_Powers1](http://discourse.iapct.org/letter_avatar_proxy/v4/letter/b/8e7dd6/32.png) [@Bill\_Powers1](http://discourse.iapct.org/u/Bill_Powers1)\
**Post date:** [November 14, 2002, 7:47pm UTC](http://discourse.iapct.org/t/science-article-on-negative-feedback-loop/10253/1 "2002-11-14T19:47:28Z")

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[From Bill Powers (2002.11.14.1238 MST)]  
Dear Bob,  
Hope your projects are moving along satisfactorily. If you have time, I’d  
appreciate a comment on this article in Science, for edification of the  
CSG list participants and me:  
Hoffman, A., Levchenko, A.,Scott, M.L., Baltimore, D. The IkB-NF-kB  
signaling module: Temporal control and selective gene activation.  
**Science 298** , 8 Nov, 2002 1241-1245.

I understand from this article that a biochemical negative feedback loop  
has been identified, together with signaling molecules that can alter its  
stability over a wide range. This loop apparently controls the  
“expression” of some gene, though my understanding falters  
right there. Could you explain more about what’s up here, so I might have  
a slight chance of understanding it?

Best regards,

Bill P.

> **···**
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> To: Bob Franza