or is it old news?
If anyone wants to pursue this, I can probably get the original for you.
Ted
New role for motor neurons discovered – ScienceDaily.pdf (606 KB)
[From MK (2016.01.15.2200 CET)]
It is relevant and only old by a day or two.
To readers of this list: Please refrain from contacting the lead
author unless you are intimately familiar with his work and the
positions held by neighbouring groups in Stockholm.
Thank you,
M
[From MK (2016.01.15.2200 CET)]
It is relevant and only old by a day or two.
To readers of this list: Please refrain from contacting the lead author unless you are intimately familiar with his work and the positions held by neighbouring groups in Stockholm.
Thank you,
M
from Ted Cloak (2016.01.15.1530 MST)
Some questions:
1. Why isn't my original post quoted in MK's reply?
2. Why wasn't my original post sent to me?
3. Why can't I view csgnet threads on lists.illinois.edu? I am logged in.
4. What is the second paragraph of MK's reply about?
5. Did any member, other than MK, receive my original post?
Ted
Ted,
I'm sorry, I mixed up this one with your earlier message on motor
neurons, about “predictive neuron orchestra”. That was the one on
which we all had responded. MK (who I know only by the initials) was
the only one commenting on the feedback circuit, and MK didn’t
actually comment.
I get Nature, so I suppose I will see the article. Then I might
comment. But I can’t help you with your connection to CSGnet.
Martin
···
On 2016/01/15 1:37 PM, Ted Cloak wrote:
or is it old news?
If anyone wants to pursue this, I canprobably get the original for you.
Ted
[From: Bruce Nevin (2016.01.23.14:40 ET)]
Ted Cloak (2016.01.15.1530 MST) –
Hi, Ted. I’m slow to pick up on your questions.
TC: 1. Why isn’t my original post quoted in MK’s reply?
BN: MK may have deleted the quoted thread. That’s the only way I know that I could accomplish that.
TC: 2. Why wasn’t my original post sent to me?
BN: I don’t see my posts returned to me until someone responds to them. It appears that the listserv assumes that you don’t intend to send it to yourself.
BN: I don’t know the answers to your other questions, except that obviously Martin and I are among those who received your original post.
BN: The authors presume an open-loop model of locomotion. Signals from the brain start up a pattern generator in the spinal column and can subsequently interfere with its rhythm e.g. if an obstacle is encountered, but otherwise it just ticks away until stopped. The motor neurons, in this view, are the equivalent of telegraph wires, efferent only.
But “motor neurons control locomotor circuit function retrogradely via gap junctions, so that motor neurons will directly influence transmitter release and the recruitment of upstream excitatory interneurons.” “Retrogradely” sounds like they’ve discovered feedback mediated through motor neurons. It smells like their open-loop concepts prevent their recognizing it. They may be on the verge of recognizing that the ‘pattern’ of locomotion is not generated in the spinal column but rather emerges from negative-feedback control in interaction with the environment. However, I’m extrapolating way beyond the limited information they provide here.
Here’s a related article:
http://www.cell.com/neuron/abstract/S0896-6273(14)00629-1
And another with a bit more popsci flavor
http://www.medicalnewstoday.com/articles/305031.php
Gap junctions have been in science news recently. They are not just in synapses, they are the means by which adjacent cells of all kinds intercommunicate, and by which subtle chemical changes can very quickly be communicated cell to cell, cumulatively over astonishingly large distances and volumes of tissue. Various substances can be transmitted directly from the cytoplasm of one cell to the cytoplasm of an adjacent cell through microtubes. (http://www.nature.com/scientificamerican/journal/v312/n5/full/scientificamerican0515-70.html)
···
On Fri, Jan 15, 2016 at 5:38 PM, Ted Cloak tcloak@unm.edu wrote:
[From MK (2016.01.15.2200 CET)]
It is relevant and only old by a day or two.
To readers of this list: Please refrain from contacting the lead author unless you are intimately familiar with his work and the positions held by neighbouring groups in Stockholm.
Thank you,
M
From Ted Cloak (2016.01.15.1530 MST)
Some questions:
Why isn’t my original post quoted in MK’s reply?
Why wasn’t my original post sent to me?
Why can’t I view csgnet threads on lists.illinois.edu? I am logged in.
What is the second paragraph of MK’s reply about?
Did any member, other than MK, receive my original post?
Ted