tracking study on Parkinson's disease

[Hans Blom, 970424h]

Some quotes from:

R.W. Watson, R.D. Jones, N.B. Sharman: Two-dimensional tracking tasks
for quantification of sensory-motor dysfunction and their application
to Parkinson's disease. Medical & Biological Engineering & Computing,
March 1997, pp. 141-145.

Tracking tasks have been extensively used since the Second World War
to provide quantitative information on the performance of the human
sensory-motor system, and to determine how the system functions in
both its normal and diseased states.

Although all of the tests in the original test battery were of a 1-D
nature, it was considered that measurement of sensory-motor function
in a 2-D environment might provide additional valuable information on
certain sensory-motor disorders. ... 2-D tasks are likely to stress
the sensory-motor system to a greater extent than 1-D tasks ... and
are thus likely to be more _sensitive_ in terms of allowing subtle
differences in sensory-motor function to be detected.

2-D random [the spot to be tracked moves continuously] and step [the
spot moves in large steps] pursuit tracking tests ... high resolution
colour monitor ... floor-mounted joystick or the computer's mouse ...
the subject's response is sampled at 30 Hz ... or 60 Hz ...

... reaction time ... rise time ... overshoot ... target entry time
[time it takes to manipulate the cross on the screen to be fully
within a target box] ... overall [integrated] error

Parkinsonian subjects cannot track a random signal as accurately as
normal subjects. ... There was no significant difference between the
gains for the two groups. ... reaction times ... target entry times
... and overall errors ... were all greater than those for the normal
group. ... The majority of step response graphs for the Parkinsonian
group exhibited the classic Parkinsonian step response of a stepped
approximation to an overdamped response

... both the normal and Parkinsonian subjects were able to use the
spatial predictability of the central target to improve their
tracking performance. This resulted in both groups showing reduced
errors ... reaction times ... and target entry times ... There was no
change in rise times.

2-D tracking performance of the Parkinsonian subjects was inferior to
their 1-D performance [unlike in the normal subjects]

... males have a slight overall performance superiority over females
on tracking tasks ... females have a lower maximum speed/acceleration

... this is the first study to show that Parkinsonian subjects are
_unimpaired_ in their ability to benefit from advance spatial
information on a step task.

Greetings,

Hans

[From Bill Powers (970424.1042 MST)]

Hans Blom, 970424h --

Some quotes from:

R.W. Watson, R.D. Jones, N.B. Sharman: Two-dimensional tracking tasks
for quantification of sensory-motor dysfunction and their application
to Parkinson's disease. Medical & Biological Engineering & Computing,
March 1997, pp. 141-145.

Very nice find! This is, however, only the first _published_ study of this
kind. When Tom Bourbon was at the U of T medical center in Houston, he was
getting set up to measure control system performance of paraplegics,
Parkinson's patients, patients with spinal-cord injuries, and "spastics." He
had built a framework with measuring potentiometers that could be used to
measure arm, leg, and torso movements in any direction around various
joints, and had started a series of pilot experiments.

In his pilot studies, Tom found essentially the same thing as reported by
Watson et. al.. People who had very poor limb control had nothing at all
wrong with their control systems except for the output function. Tom and I
were thinking of some VERY simple fixes that would allow precise control,
such as filtering the effect of the control handle on the display to
eliminate the random component of the output and up the gain for the low
frequency part of the output. This might have allowed good control, even if
it would be slower.

Then a bunch of neurosurgeons came back from a meeting all pumped up about a
new kind of rat experiment, with the result that they took not only all of
Tom's research money away to fund the new project, but his salary, too.
Tough luck, buddy.

And Bruce asks, "Why hasn't PCT produced more research?"

Best,

Bill P.