[Martin Taylor 2012.01.22.16.58]]
No specific earlier reference, but I think this abstract from a paper by Evan Charney submitted to BBS for commentary might help support at least the feasibility of Bill P's suggestion that reorganization of the genome over evolutionary time might be a control process. I had been asking where the information that would have to be transmitted per gene might be transmitted, and had suggested the possibility that it might be in the so-called noncoding DNA. This abstract seems to suggest another possibility that might act at a different level than the individual genes.
The science of genetics is undergoing a paradigm shift. Recent discoveries, including the activity of retrotransposons, the extent of copy number variations, somatic and chromosomal mosaicism, and the nature of the epigenome as a regulator of DNA expressivity, are challenging a series of dogmas concerning the nature of the genome and the relationship between genotype and phenotype. DNA, once held to be the unchanging template of heredity, now appears subject to a good deal of environmental change; considered to be identical in all cells and tissues of the body, there is growing evidence that somatic mosaicism is the normal human condition; and treated as the sole biological agent of heritability, we now know that the epigenome, which regulates gene expressivity, can be inherited via the germline. These developments are particularly significant for behavior genetics for at least three reasons: First, these phenomena appear to be particularly prevalent in the human brain, and likely are involved in much of human behavior; second, they have important implications for the validity of heritability and gene association studies, the methodologies that largely define the discipline of behavior genetics; and third, they appear to play a critical role in development during the perinatal period, and in enabling phenotypic plasticity in offspring in particular. I examine one of the central claims to emerge from the use of heritability studies in the behavioral sciences, the principle of "minimal shared maternal effects," in light of the growing awareness that the maternal perinatal environment is a critical venue for the exercise of adaptive phenotypic plasticity. This consideration has important implications for both developmental and evolutionary biology.
I don't intend to comment on the article, but if the thought seems relevant you may want to look at it if and when it gets published, or to look for the evidence that leads to the lead statements in the abstract.